Philip J. Laipis, Ph.D


Professor and Associate Chair
Department of Biochemistry and Molecular Biology
University of Florida College of Medicine

R3-216B Academic Research Building
P.O. Box 100245
Gainesville, FL 32610-0245
(352) 392-0121 voice; laboratory 392-6493

Laboratory Focus

My research interests are in the area of eukaryotic gene regulation, organization, and evolution. I have a strong interest in genetic diseases and approaches to their treatment by both recombinant DNA techniques and recombinant enzyme replacement/substitution therapies.

At the present time, research in the laboratory is focused on the genetic disorder Phenylketonuria (PKU). We are participating in a clinical study using enzyme replacement therapy with the enzyme Phenylalanine Ammonia Lyase as well as examining the pathophysiology of PKU in the Pahenu2 PKU mouse model of the disease. Our goals are the development of 1) a new clinical therapy for human PKU patients and 2) a better understanding of the basic disease process that will lead to new therapeutic approaches.